49ers vs. Saints prediction, odds, line, spread: 2022 NFL picks, Week 12 best bets from proven computer model

Jimmy Garoppolo and the San Francisco 49ers (6-4) look to stay hot when they host Andy Dalton and the New Orleans Saints (4-7) in a NFL Week 12 matchup at Levi's Stadium on Sunday. The Niners are riding a three-game winning streak after blowing out the Arizona Cardinals on Monday Night Football in Mexico City. Meanwhile, the Saints are looking to build off their 27-20 win over the Los Angeles Rams in Week 11. New Orleans is 4-7 against the spread, while San Francisco is 5-5 ATS in 2022.

Kickoff is at 4:25 p.m. ET. San Francisco is favored by 9 points in the latest 49ers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 43. Before entering any Saints vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.